💡Conclusion 1:
From the perspective of entropy, the interface area often has the biggest impact on the affinity between the two complex meaning that the largest the interface area, the highest affinity within the complex.
Review here👉 Large Interface Group Medium Interface Group Small Interface Group
💡Conclusion 2:
Additionally, the shape of the interface contributes significantly to the affinity between the complex.
Review here👉 CHL4-AME1 IML3-CTF3
💡Conclusion 3:
It is worth mentioning that even though the overall hydrophobic percentage is high in the interface area, still the hydrophobic residues do not interact with other hydrophobic ones. Thus this mismatch within the interface does not contribute the affinity.
Review here👉 CHL4-CTF19 CHL4-MCM21
💡Conclusion 4:
For the two chains with the large interface, the impact of the conformational entropy on the two chains is limited.
Review here👉 CHL4-MCM21 CHL4-IML3
💡Conclusion 5:
The complex formed by two chains with a larger interface often plays an obvious and important biological role.
Review here👉 Large Interface Group
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