CHL4 (Cenp-N) C-terminal interfaces in details
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☞ IML3:CHL4 ☞ CHL4:MCM21 ☞ CHL4:CTF19 ☞ MCM16:CHL4
ALL Major Interfaces Involving Cenp-N C-terminal PERFECTLY complemented
Interface N:P (CHL4:CTF19)
The shape of this CHL4:CTF19 interface is described as a convex:concave type. The amino acids on CTF19 involved in the interface formation are separated into two groups, resembling a pair of tongs and awaiting the residues from its paired subunit. In contrast, the residues on CHL4 have a doughnut-like distribution, with one side more dominated with residues.
Whilst the bulk of residues from CHL4 try to sit in the 'concaved' sites of CTF19, the lighter side is assumed to help to correct recognition and arrangement of these major interactions.
The hydrophilic residues are condensed on one side on CHL4 and are spread across on the CTF19 interface.
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CHL4:CTF19 forms a convex:concave interface. The convex distribution of residues on CHL4 fit into the concave shape of CTF19, with the 'lighter' side of the doughnut-distribution sitting within one region of the CTF19 interface upon interaction.