The Kinetochore
Kinetochore composition
Kinetochores are multi-protein macromolecular complexes that assemble onto centromeric DNA and are required for establishing bipolar spindle-microtubule attachments, mediating sister chromatid segregation during cellular division.1 In addition, they coordinate chromosome folding and serve as error-correcting and signalling hubs that control cell cycle progression.2,3 The inner kinetochore CCAN interacts with centromeric chromatin forming a structural platform for outer kinetochore assembly. 1,4
References
1. Cheeseman, I. M. et al. Phospho-regulation of kinetochore-microtubule attachments by the Aurora kinase Ipl1p. Cell 111, 163–172 (2002).
2. Biggins, S. The composition, functions, and regulation of the budding yeast kinetochore. Genetics 194, 817–846 (2013).
3. Hinshaw, S. M., Dates, A. N. & Harrison, S. C. The structure of the yeast Ctf3 complex. Elife 8, (2019).
4. Maiato, H., DeLuca, J., Salmon, E. D. & Earnshaw, W. C. The dynamic kinetochore-microtubule interface. Journal of Cell Science 117, 5461–5477 (2004).
5. Wikipedia, 2010. Kinetochore structure and components in vertebrate cells. Based on Maiato et al. (2004). Available at: https://en.wikipedia.org/wiki/Kinetochore?fbclid=IwAR1IY4_KHKHmB3DUqz_V0zvXZMOkhqlJZjVL6rrlOtmIomNaT_sJ4GzFW0Q#/media/File:Kinetochore_vertebrates-en.png