Interface conservation between IML3/CHL4 complex and other CCAN proteins

Items

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  interactionN-P(O)

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  Interface residues of CENP-L in CENP-N:CENP-L

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  Conservation in N-L interface

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  Interface of IML3 interacting with CTF3

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  Interactions-NL

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  Conservation of the Cenp-N interface in the interaction with Cenp-P

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  Conservation of Cenp-N interface in the interaction with Cenp-O

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  Fig.2 Inference of conservation

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  Fig.1 Contribution of conservation to interfaces

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  Small in size interfaces of Cenp-N subunit

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  Salt bridge between IML3 and CTF3

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  H-bonds of Cenp-L/I interface

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  H-bond between Cenp-L/N (Asn391-Glu195)

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  H-bond between IML3 and CHL4

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  Cenp-LN complex-rotating model

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  Multiple sequence alignment of metazoan and vertebrate IML3 homologous proteins with focus on LI interface

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  Multiple sequence alignment of metazoan and vertebrate IML3 homologous proteins with focus on LN interface

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  LNI-Conservation

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  IML3-CTF3 Interface

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  IML3-CHL4 Interface

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  Table 1 Interface consists of IML3

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  Fig.2 Involved atoms classified by hydrophobicity and hydrophilicity

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  Fig.1 Residues scaled by hydrophobicity

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  Fig.2 Distribution of contact bonds

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  Fig.1 Distribution of BSA and number of atoms